kings of the highway

blue highway: jason burleson, shawn lane, wayne taylor, tim stafford and rob ickes. photo by scott simontacchi.

You check the itinerary first and then do a double take. Is Blue Highway really playing Cosmic Charlie’s?

“Yeah, we’re going rock ‘n’ roll,” said dobro ace Rob Ickes of the band’s visit tonight to the club known more for its diet of local pop showcases, jam band shows and rock outings. “Just kidding.”

Granted, bluegrass makes an occasional bow at Cosmic Charlie’s. But the most common local outlet for Blue Highway’s mainstream string music appeal has been the annual Festival of the Bluegrass in June. But indoors? At what is predominantly a rock club?

“We’re looking forward to it,” Ickes added. “We just want to spread the word.”

The “word” on Blue Highway has been continually favorable. Formed in 1994, it brought together a trio of champion songwriters, alert harmony singing and stylistic appeal that, while very much bluegrass, doesn’t shy away from side trips into folk and country. And in Ickes, the band possesses unyielding instrumental firepower. He has won Dobro of the Year honors from the International Bluegrass Music Association 13 times over the last 16 years.

But the journey along Blue Highway didn’t begin in Ickes’ current home base of Nashville. He grew up in the San Francisco Bay area, a region known to mining progressive ideas for bluegrass tradition. He sensed, however, a sense of job security when he teamed with Blue Highway mates Tim Stafford (on guitar), Wayne Taylor (bass), Shawn Lane (mandolin, guitar and fiddle) and Jason Burleson (banjo). It was still a curious move, as Blue Highway was then an untested bluegrass commodity.

“It’s funny. I just had a feeling when we started that this band was going to be a long term thing. I don’t know if any of the other guys did. But it’s become like family. I really sense that once we’re in the studio. There is always a level of trust you can count on. You know things are going to happen on a certain level. We keep challenging each other.”

Ickes offers the band’s most recent album, 2011’s Sounds of Home, as evidence. It meshes songs and styles that shift from steadfast traditionalism (Lane’s I Ain’t Gonna Lay My Hammer Down) to folkish narrative (Storm, also by Lane) to rootsy efficiency (an Appalachian flavored treatment of the blues standard Nobody’s Fault But Mine). And for instrumental fire, there is Burleson’s Roaring Creek, which lets loose Ickes’ wiry ingenuity on the dobro.

“We have less of a game plan every time we go in to make a record,” Ickes said. “We’ve got three great writers (Stafford, Lane and Taylor; four if you include Burleson and his instrumental compositions) who write a lot. Typically we have about 30 songs to choose from when we go into the studio. One of the hardest parts of making a record can be finding good material. We’ve been lucky in that respect.

“Then all of a sudden, it’s like, ‘Hey, we’ve got a country tune and a folk tune here.’ But it’s not like we plan all that out. We used to. Now we just go in and do it. That seems to work. The songs are always what keep us excited.”

But part of what has made Ickes’ move from the West Coast so rewarding is what he accomplishes outside of the band. An avid jazz enthusiast, he maintains an active solo career which most recently yielded an album of dobro/piano duets called Road Song. He also works on occasion with the string music trio Three Ring Circle with fiddler Andy Leftwich (from Ricky Skaggs’ Kentucky Thunder band) and bassist Dave Pomeroy. Its 2011 album Brothership, ventured far outside bluegrass parameters to cover such jazz delicacies as Ralph Towner’s Anthem and John Scofield’s A Go-Go.

Anthem is just one of those songs that always freaked me out. It has this very simple melody. But there is something really deep about it.”

If that didn’t fill up every spot on Ickes’ musical plate, he also serves as an auxiliary member of The Tony Rice Unit, the jazz/bluegrass hybrid band whose records greatly inspired his playing. Ickes played here with Rice at the Kentucky Theatre as recently as September.

“Tony’s music has always meant so much to me, and to so many players of my generation. His records are kind of the reason we play music.

“I guess I never really wanted to be dependent completely on one band for my musical stimulation, or whatever you want to call it. I’m into a lot of different things. That’s the main reason I moved to Nashville from California. There is so much music going on there. I get to work with other artists and on solo projects. So when I go to work with Blue Highway, I know I can help us make better records. I can bring more to the table.”

Blue Highway performs at 8 p.m. Feb.10 at Cosmic Charlie’s. 388 Woodland Ave. Tickets are $12, $15. Call (859) 309-9499.

Cold Spring Harbor Laboratory Shows Correcting RNA Splicing May Help Treat Spinal Muscular Atrophy; PLoS Biology Publishes ‘Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon’. website spinal muscular atrophy

Ascribe Higher Education News Service March 12, 2007 Byline: Cold Spring Harbor Laboratory COLD SPRING HARBOR, N.Y., March 12 (AScribe Newswire) — RNA splicing antisense technology studied at Cold Spring Harbor Laboratory (CSHL) effectively corrected an mRNA splicing defect found in spinal muscular atrophy (SMA) patients, and is now ready to be tested in mouse models. “SMA patients who suffer from motor-neuron degeneration may benefit from our ability to correct the mRNA splicing defect that makes their SMN2 genes only partially functional,” suggested CSHL Professor Adrian Krainer, Ph.D.

RNA splicing antisense technology allows researchers to influence the ultimate structure and function of proteins. Proteins are synthesized from instructions coded in the DNA through a multi-step process that includes RNA splicing. Information stored in the DNA of genes is transcribed into immature “pre-messenger RNAs” (pre-mRNAs), pre-mRNAs are then spliced into mature “messenger RNAs” (mRNAs), and finally, mRNAs are translated into proteins. In humans and most other organisms, the splicing process thus ensures proper protein production.

“Targeting the splicing process is a promising strategy for finding new medicines to treat SMA, and possibly other diseases,” said Marcus Rhoades, Ph.D. of the National Institute of General Medical Sciences, which partially supported Krainer’s research. “This work brings us one step closer to that goal.” The defect in SMN2 gene expression in SMA patients is at the level of pre-mRNA splicing, such that exon 7 tends to be left out of the mRNA that ultimately makes SMN protein. Several strategies have been pursued to increase the extent of exon 7 inclusion in the splicing of SMN2, for eventual use as therapeutics for SMA. The Krainer team, in collaboration with a team at Isis Pharmaceuticals, surveyed a large number of antisense oligonucleotides (ASOs) and found that some of these ASOs are able to correct the mRNA splicing defect in cultured cells from SMA patients. These powerful ASOs are identified by the Krainer team as viable for testing in mouse models – the next step in the process of developing new human therapies.

“Families and advocates are very pleased to see the advancement of this antisense technology for the treatment of spinal muscular atrophy. We have high hopes for the success of the next phase of the work”, said Cynthia Joyce, Executive Director of the SMA Foundation, an advocacy group that provides financial support for this project at CSHL.

The results of the research led by Krainer are published on March 13, 2007 by PLoS Biology:

The paper’s full citation is as follows:

Hua Y, Vickers TA, Baker BF, Bennett CF, Krainer AR (2007) Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon. PLoS Biol 5(4): e73. doi:10.1371/journal.pbio.0050073 CSHL is a private, non-profit research and education institution dedicated to exploring molecular biology and genetics in order to advance the understanding and ability to diagnose and treat cancers, neurological diseases, and other causes of human suffering. For more information visit www.cshl.edu About Spinal Muscular Atrophy Spinal muscular atrophy is a genetic disease that causes the degeneration of spinal cord motor neurons and leads to progressive muscle weakness, atrophy and inability to walk or sit, and breathing difficulties. Children afflicted with this disease suffer a premature death due to respiratory failure, generally before reaching two years of agee. . The SMA Foundation estimates that currently over 50,000 people suffer from SMA in the U.S., Europe and Japan and that a conservative annual market potential for an SMA treatment could exceed $500 million. go to web site spinal muscular atrophy

About the Spinal Muscular Atrophy Foundation The Spinal Muscular Atrophy Foundation is a nonprofit organization dedicated to accelerating progress towards a treatment and cure for spinal muscular atrophy through targeted funding of clinical research and novel drug development efforts. Since 2003, the Foundation has awarded over $30 million in sponsored research agreements. In addition, the Foundation is committed to raising awareness and generating support for increased research efforts in SMA among the leaders of industry and government. For more information visit www.smafoundation.org or call (000)-000-0000.

- – - – CONTACTS: Adrian Krainer is available for comment at krainer@cshl.edu. For media assistance, contact Dagnia Zeidlickis (000)-000-0000, zeidlick@cshl.edu.

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